Bipolar 1 disorder (acute manic phase). Bipolar disorder, current episode manic severe with psychotic features
Conditions
Interventions
Intervention 1: Intervention group: receive loading dose of lithium carbonate (20 mg/kg) in form of a stat dose. Intervention 2: Control group: this group receives routine dose of Lithium carbonate (3
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: known cases of Bipolar type 1 disorder (B1D) Acute manic phase No consumption of lithium carbonate since at least ten days ago.
Exclusion criteria
Exclusion criteria: patients with each kind of cardiac conditions or any positive past history of cardiac diseases- any abnormal findings in their first ecg during this admission(arrhythmia, ST change,...) positive history of psoriasis hypothyroidism or hyperthyroidism cases of chronic kidney disease or acute kidney injury any allergy or history of anaphylaxis with lithium carbonate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grades on basis of Young mania rating scale (YMRS). Timepoint: days: 0- 3-7-14. Method of measurement: (YMRS)Young mania rating scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ecg change. Timepoint: pre medication (day 0), day 3, day 7, day 14. Method of measurement: any ecg change in comparison with baseline.;Renal function. Timepoint: day 0,5,10. Method of measurement: serum bun, cr.;Serum lithium level. Timepoint: day 0,7,14. Method of measurement: serum lithium lab test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEbrahim Moghimi Sarani
Shiraz University of Medical Sciences
Outcome results
None listed