Side effects of Duloxetine plus Electroconvulsive therapy in depression

Comparison of the side effects of treatment with Duloxetine plus Electroconvulsive therapy and Sertraline plus Electroconvulsive therapy in patients with treatment resistant major depression

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181204041847N1

Enrollment

Registered

2018-12-17

Start date

2018-12-10

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment resistance depression diagnosed by psychiatrist based on DSM5 criteria. Severe depressive episode without psychotic symptoms

Interventions

Intervention 1: Intervention group: Duloxetine plus Electroconvulsive therapy. Intervention 2: Control group: Serteralin plus Electroconvulsive therapy.

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Treatment resistance depression diagnosed by psychiatrist based on DSM5 criteria

Exclusion criteria

Exclusion criteria: Other medical condition Neurological disorder Cardiovascular disease Contraindication to duloxetine and/ or Sertraline Current using other antidepressant(s) or drugs with possible effect on ECT Any contraindication for ECT

Design outcomes

Primary

Measure	Time frame
Body pain. Timepoint: After each ECT. Method of measurement: History.;Nausea. Timepoint: After each ECT. Method of measurement: History.;Convulsion duration. Timepoint: During ECT. Method of measurement: Time duration with timer.;Electrocardiogram. Timepoint: Before and after each ECT. Method of measurement: Electrocardiogram.;Headache. Timepoint: After each ECT. Method of measurement: History.;Cognition. Timepoint: Before and after ECT. Method of measurement: Mini mental status examination.	—

Measure

Time frame

Body pain. Timepoint: After each ECT. Method of measurement: History.;Nausea. Timepoint: After each ECT. Method of measurement: History.;Convulsion duration. Timepoint: During ECT. Method of measurement: Time duration with timer.;Electrocardiogram. Timepoint: Before and after each ECT. Method of measurement: Electrocardiogram.;Headache. Timepoint: After each ECT. Method of measurement: History.;Cognition. Timepoint: Before and after ECT. Method of measurement: Mini mental status examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEbrahim Moghimi-Sarani

Shiraz University of Medical Sciences

moghimie@sums.ac.ir+98 71 3227 1387

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026