Effectiveness of Aspirin 80, Aspirin 325, Enoxaparin and Rivoroxaban in Prevention of Coagulopathy after Total Knee Arthroplasty

Comparison study on Effectiveness of Aspirin 80, Aspirin 325, Enoxaparin and Rivoroxaban in Prevention of Coagulopathy after Total Knee Arthroplasty

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181128041784N1

Enrollment

124

Registered

2019-03-05

Start date

2018-12-23

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis. Unilateral primary osteoarthritis of knee

Interventions

Intervention 1: Intervention group: First group: 80 mg of aspirin,acetylsalicylic acid, twice daily, oral, up to three weeks. Intervention 2: Intervention group: . Second group: 325 mg of Aspirin, ace

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with definite diagnosis of osteoarthritis, rheumatoid arthritis or joint destruction Patients are candidates for knee replacement because of pain and severe motor limitation

Exclusion criteria

Exclusion criteria: History of skin allergy, respiratory or allergic to aspirin History of the use of anticoagulant and hemorrhagic diseases History of malignancy History of liver and kidney disease

Design outcomes

Primary

Measure	Time frame
Deep vein Thrombosis. Timepoint: 1, 2 and 6 week. Method of measurement: Venous Doppler Ultrasonography.	—

Secondary

Measure	Time frame
Pulmonary thromboembolic. Timepoint: 1, 2 and 6 week. Method of measurement: CT Angiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamreza Ghorbaniamjad

Hamedan University of Medical Sciences

Amjad52m@yahoo.com+98 81 3264 0020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026