Evaluating the effect of ketamine and remifentanil combination with ketamine and propofol on pain and agitation

Comparing the effect of ketamine and remifentanil combination with ketamine and propofol combination on pain, agitation and hemodynamic changes in patients undergoing closed nasal bone reduction

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181127041768N1

Enrollment

Registered

2018-12-08

Start date

2018-08-23

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain.

Interventions

Intervention 1: Intervention group: In the first intervention group, 0.75 mg/kg of ketamine and 2 µg/kg of remifentanil are injected for induction of anesthesia. Intervention 2: Intervention group: In

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: ASA status equal to 1 The patient undergoes nose bone closed fracture reduction Age from 18 to 60 years old.

Exclusion criteria

Exclusion criteria: History of Hypertension Hyperthyroidism Mental disorders History of coronary artery disease Drug use

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: After surgery in the recovery room and every 15 minutes to 2 hours. Method of measurement: Based on Numeric Rating Scale.;Agitation. Timepoint: After surgery in the recovery room and every 15 minutes to 2 hours. Method of measurement: Based on Richmond Agitation-Sedation Scale.;Hypertension. Timepoint: Every 15 Minutes. Method of measurement: Using the vital signs monitoring device.;Heart rate. Timepoint: Every 15 Minutes. Method of measurement: Using the vital signs monitoring device.	—

Measure

Time frame

Pain. Timepoint: After surgery in the recovery room and every 15 minutes to 2 hours. Method of measurement: Based on Numeric Rating Scale.;Agitation. Timepoint: After surgery in the recovery room and every 15 minutes to 2 hours. Method of measurement: Based on Richmond Agitation-Sedation Scale.;Hypertension. Timepoint: Every 15 Minutes. Method of measurement: Using the vital signs monitoring device.;Heart rate. Timepoint: Every 15 Minutes. Method of measurement: Using the vital signs monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzadeh Fathi

Sanandaj University of Medical Sciences

a.fathi@muk.ac.ir+98 87 3361 1233

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026