Obstructive sleep apnea/L-citruline effect on artery. Obstructive sleep apnea (adult) (pediatric)
Conditions
Interventions
Intervention 1: Intervention group: patients are divided into 2 groups by block randomization and by stratification protocol we try that the diabetes dispersion be the same in both groups. For our int
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who are categorized as moderate to severe according to AHI criteria by using polysomnography The ones that clinical ultrasonography proves that the patient has endothelial dysfunction (FMD> NMD) Patients the their arterial muscular dysfunction has been ruled out
Exclusion criteria
Exclusion criteria: If less than 40 days have been passed from patien's OSA treatment Hx of coronary artery disease (>50% of arterial occlusion, or any background PCI or CBAG) Ischemic heart disease Smoking Patients who do not have endothelial dysfunction (FMD ratio to normal vessel diameter is more than one) Receiving any medication that affects endothelial function unless 4 half-life of the drug has been passed since its last consume.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial artery diameter. Timepoint: The beginning and the end of the study. Method of measurement: colour doppler ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily sleepiness. Timepoint: at the beginning and the end of the study. Method of measurement: Epworth sleepness scale questionnaire.;Depression rate. Timepoint: The beginning and the end of the study. Method of measurement: patients health questionnaire-9.;Dislipidemia. Timepoint: The beginning and the end of the study. Method of measurement: Patient case. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeed Nateghi
Tehran University of Medical Sciences
Outcome results
None listed