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Effect of fluoride and xylitol varnish on oral microorganism

The effect of combination of xylitol and fluoride varnish on microbial biofilm and saliva in fixed orthodontic patients: a randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181121041713N4
Enrollment
120
Registered
2021-10-12
Start date
2021-10-11
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cariogenic bacteria in the oral cavity.

Interventions

Intervention 1: Intervention group: first/fluoride varnish/sodium fluoride 5 percentage(Product of Asia Chemi Teb Pharmaceutical Company) / two drops of varnish/fluoride varnish is applied to the teet

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 30 Years

Inclusion criteria

Inclusion criteria: Age between 12 and 30 years old Permanent dentition Good general health No anti-inflammatory or antibiotic medications taken in the month before the study No chewing gum or mouthwash use in the last week and during the study Brushing twice daily with fluoride toothpaste No active or untreated caries lesions or gingival inflammation

Exclusion criteria

Exclusion criteria: Treatment with antibiotics, steroids or any medication known to cause dry mouth in the last 3 months Poor oral hygiene Active periodontal disease Sever crowding of anterior teeth that would be likely to interfere with cleaning of tooth surface Smoking History of mouth breathing

Design outcomes

Primary

MeasureTime frame
Number of bacterial colonies. Timepoint: Before beginning the intervention and 45 days later. Method of measurement: Counting the number of bacterial colonies.

Secondary

MeasureTime frame
. Timepoint: . Method of measurement: .

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Neda Babanouri

Shiraz University of Medical Sciences

nedababanouri@yahoo.com+98 71 3628 0801

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026