Effect of Bromelain and Turmeric on orthodontic pain

Evaluation of the the efficacy of bromelain and turmeric on pain after orthodontic separator placement: A single center, triple blind, randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181121041713N3

Enrollment

135

Registered

2020-10-06

Start date

2020-11-20

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Evaluation of pain intensity after separator placement in orthodontics patients..

Interventions

Intervention 1: Intervention group: 200 mg Bromelain. Intervention 2: Intervention group: 150 mg Bromelain + 300 mg Turmeric. Intervention 3: Control group: 400 mg Ibuprofen.

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: Need separator placement to begin orthodontic treatment in the maxillary arch Aged 15 years or older Not currently using antibiotics, analgesics, anti – inflammatory, anti-coagulative, diuretics, oral anti diabetics, lithium, cyclosporine and methotrexate No need for antibiotic prophylaxis Not pregnant or nursing

Exclusion criteria

Exclusion criteria: Extraction or missing of any maxillary teeth except from third molars Smoking Patients with chronic systemic diseases or clotting disorders Reporting contraindication for NSAIDs, Bromelain and Turmeric Reporting allergy to pineapple

Design outcomes

Primary

Measure	Time frame
Evaluation of pain intensity after elastic-separators placement in orthodontic patients. Timepoint: 2, 6, 24 and 48 hours after elastic-separators placement. Method of measurement: The Visual Analogue Scale (VAS) is used to determine the level of pain and discomfort.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Neda Babanouri

Shiraz University of Medical Sciences

babanouri@sums.ac.ir+98 71 3628 0801

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026