The Effect of a Debridement Cream on Necrotic Tissue Removal and Prevention of Infection and Inflammation Caused by Mechanical Debridement in Deep Second-Degree Burns.

Preparation and evaluation of a wound debridement cream containing liposomal nanoparticles loaded with plant-derived enzymes in patients with deep second-degree burn wounds.

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181118041688N1

Enrollment

Registered

2026-05-11

Start date

2025-09-23

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep second-degree burn wounds. Open wound of hand

Interventions

Intervention 1: Intervention Group: Patients with deep second-degree burn wounds will receive a debridement cream containing plant-derived enzymes, free of chemical compounds. The cream will be applie

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patients diagnosed with deep second-degree burns are eligible for inclusion in the study. Patients must have 2to3 deep second-degree burn wounds.

Exclusion criteria

Exclusion criteria: Senescence individuals are considered eligible for exclusion. All patients with first-degree burns are considered eligible for exclusion. Pediatric patients with burns are considered eligible for exclusion. Pregnant women with burns are considered eligible for exclusion.

Design outcomes

Primary

Measure	Time frame
Burn wound debride. Timepoint: from 30 minutes to 1 hours. Method of measurement: Image J.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdolkhalegh Keshavarzi

Shiraz University of Medical Sciences

iliakeshavarzi@yahoo.com+98 71 3212 2220

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026