Comparing dimethyl sulfoxide solution versus topical tretinoin in cutaneous amyloidosis

Comparing the efficacy of 50% dimethyl sulfoxide solution versus topical tretinoin 0.5% cream in patients with cutaneous amyloidosis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181114041658N1

Enrollment

Registered

2019-02-24

Start date

2019-03-21

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary localized cutaneous amyloidosis. Organ-limited amyloidosis

Interventions

Intervention 1: Intervention group receives topical dimethyl sulfoxide (DMSO) 50% solution (formulized and prepared at the School of Pharmacy, Shiraz University of Medical Sciences) on the assigned si

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with clinical and pathological diagnosis of lichen and macular amyloidosis in trunk and lower limbs bilateral amyloidosis

Exclusion criteria

Exclusion criteria: using other topical drugs in last four weeks sensitivity to retinoids hepatic disorders breast feeding pregnancy no consent for photography

Design outcomes

Primary

Measure	Time frame
Melanin. Timepoint: baseline and at the end of 4th, 12th, and 18th week of 20-week treatment period. Method of measurement: colorimetery (dermocatch).;Itching. Timepoint: baseline and at the end of 4th, 12th, and 18th week of 20-week treatment period. Method of measurement: itching scoring (0-10).;Erythema. Timepoint: baseline and at the end of 4th, 12th, and 18th week of 20-week treatment period. Method of measurement: colorimetery (dermocatch).	—

Measure

Time frame

Melanin. Timepoint: baseline and at the end of 4th, 12th, and 18th week of 20-week treatment period. Method of measurement: colorimetery (dermocatch).;Itching. Timepoint: baseline and at the end of 4th, 12th, and 18th week of 20-week treatment period. Method of measurement: itching scoring (0-10).;Erythema. Timepoint: baseline and at the end of 4th, 12th, and 18th week of 20-week treatment period. Method of measurement: colorimetery (dermocatch).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNajmeh Ahramyianpour

Shiraz University of Medical Sciences

najmeh.pour@gmail.com+98 71 3235 1087

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026