Effects of alpha-lipoic acid supplementation in gestational diabetes mellitus

Alpha-lipoic acid supplementation effects on serum values of catalase, thiol groups, oxidative stress index and homeostasis model assessment of beta-cell function (HOMA-B) in women with gestational diabetes

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181113041639N1

Enrollment

Registered

2019-05-25

Start date

2019-08-31

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational diabetes mellitus. Diabetes mellitus arising in pregnancy

Interventions

Intervention 1: Intervention group: Intervention group: One capsule alpha-lipoic acid (300 mg) per day for 8 weeks. Intervention 2: Control group: Control group: One capsule placebo cellulose acetate

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: No history of gestational diabetes mellitus From 18 years old to 40 years old No smoking

Exclusion criteria

Exclusion criteria: consumption of vitamin and mineral supplements during the last 6 months Preterm delivery Unwillingness to cooperate Preeclampsia and other complications pregnancy during intervention Thyroid disorders Thalassemia Severe anemia Autoimmune diseases Digestive diseases Insulin therapy Oral glucose lowering drugs consumption Bed rest

Design outcomes

Primary

Measure	Time frame
Fasting glucose. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Antioxidant capacity. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Total oxidant status. Timepoint: Before and after 8 weeks of intervention. Method of measurement: ?????????.;Stress oxidative index. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Formula.;Glutathione. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Spectrophotometric.;BMI. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Formula.;Catalas. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Spectrophotometric.;Insulin. Timepoint: Before and after 8 weeks of intervention. Method of measurement: ELISA.;Malondialdehyde. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;HOMA-B. Timepoint: Before and after 8 weeks of intervention. Method of measurement: formula.	—

Measure

Time frame

Fasting glucose. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Antioxidant capacity. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Total oxidant status. Timepoint: Before and after 8 weeks of intervention. Method of measurement: ?????????.;Stress oxidative index. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Formula.;Glutathione. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Spectrophotometric.;BMI. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Formula.;Catalas. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Spectrophotometric.;Insulin. Timepoint: Before and after 8 weeks of intervention. Method of measurement: ELISA.;Malondialdehyde. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;HOMA-B. Timepoint: Before and after 8 weeks of intervention. Method of measurement: formula.

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Secondary

Measure	Time frame
BMI. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoome Mamdani

Arak University of Medical Sciences

masoomemandany@gmail.com+98 86 3417 3501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026