Cesarean delivery. Onset (spontaneous) of labor after 37 completed weeks of gestation but before 39 completed weeks gestation, with delivery by (planned) cesarean section
Conditions
Interventions
Intervention 1: Intervention group: Intrathecal injection of 2.5 ml of Bupivacanie 0.5% (Astra Zeneca company, Sweden) plus 5 µg of Dexmedetomidine (Pfizer company, US) (total volume of 3.0 ml). Inte
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Pregnant women with repeated cesarean delivery and more than 39 gestational age Age between 18 to 40 years old Candidate for elective cesarean delivery underwent spinal anesthesia American Society of Anesthesiologists (ASA) physical status classification system I and II Without history of asthma, cardiovascular diseases, diabetes, acute and chronic renal failure, deep vein thrombosis, pulmonary embolism, peripheral vascular diseases, preeclampsia, eclampsia, seizure, convulsion, and cancers Without history of drug abuse or sedative & hypnotic drugs Without congenital malformation Without history of airway problems and systemic diseases, and preterm labor Without history of medication allergy Without coagulopathy Hemoglobin level above 10 g/dl Normal level of clotting time (CT), bleeding time (BT), prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR) Having at least two clinical visit with obstetrician and one blood test and 2 control sonography during pregnancy in pregnancy record Filling the informed consent form
Exclusion criteria
Exclusion criteria: Use of sedative and hypnotic drugs before surgery Use of anticoagulants 48 hours before surgery With psychiatric disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters (heart rate and blood pressure). Timepoint: Before and 1, 5,15, 30 and 60 minute after surgery. Method of measurement: Vital-signs monitoring device. | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal pain. Timepoint: Before and 1, 6, 12 and 24 hours after surgery. Method of measurement: Visual analogous scale.;Neonatal APGAR. Timepoint: 1st and 5th minute after birth. Method of measurement: APGAR scale.;Arterial blood gases. Timepoint: After birth. Method of measurement: Arterial blood gases analysis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMonireh Jahani
Gorgan University of Medical Sciences
Outcome results
None listed