Effects of dexmedetomidine on septic shock ICU patients

Effects of dexmedetomidine on serum level of inflammatory factors in septic shock ICU patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181104041551N2

Enrollment

Registered

2020-05-12

Start date

2018-08-23

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock. Severe sepsis with septic shock

Interventions

Intervention 1: The Intervention group receives Dexmedetomidine vial made by Hospira Co. with the brand name of Precedex, with a dose of 1 µg/kg for 10 minutes and then 0.2-2.5 µg/kg/h for 24 hours. I

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with septic shock over 18 years old

Exclusion criteria

Exclusion criteria: History of beta-blockers using Heart block or sick sinus syndrome Norepinephrine greater than 10 mcg/kg/min

Design outcomes

Primary

Measure	Time frame
Serum level of Inflammatory factor IL-1. Timepoint: Before the use of dexmedetomidine and after 24 hours. Method of measurement: ELISA test.;Serum level of Inflammatory factor IL-6. Timepoint: Before the use of dexmedetomidine and after 24 hours. Method of measurement: ELISA test.;Serum level of Inflammatory factor TNF-a. Timepoint: Before the use of dexmedetomidine and after 24 hours. Method of measurement: ELISA test.	—

Measure

Time frame

Serum level of Inflammatory factor IL-1. Timepoint: Before the use of dexmedetomidine and after 24 hours. Method of measurement: ELISA test.;Serum level of Inflammatory factor IL-6. Timepoint: Before the use of dexmedetomidine and after 24 hours. Method of measurement: ELISA test.;Serum level of Inflammatory factor TNF-a. Timepoint: Before the use of dexmedetomidine and after 24 hours. Method of measurement: ELISA test.

—

Secondary

Measure	Time frame
Investigation of the sedative effects of dexmedetomidine. Timepoint: Baseline and after 24 hours. Method of measurement: Richmond agitation-sedation scale.;Changing norepinephrine dose of. Timepoint: Baseline and after 24 hours. Method of measurement: Clinical observation.;Changing in Sofa score. Timepoint: Baseline and after 24 hours. Method of measurement: checklist.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Fatemeh Heydari

Mazandaran University of Medical Sciences

f.heydari@mazums.ac.ir+98 11 3336 1701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026