Intramuscular methotrexate on adhesive capsulitis of the shoulder

Therapeutic efficacy of intramuscular methotrexate versus oral naproxen in adhesive capsulitis of the shoulder: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181101041523N1

Enrollment

Registered

2022-12-20

Start date

2019-01-30

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adhesive capsulitis of the shoulder. Adhesive capsulitis of shoulder

Interventions

Intervention 1: Intervention group: Intramuscular methotrexate (12.5 mg every 10 days for 40 days). Intervention 2: Intervention group: Oral Naproxen (500 mg Daily for 40 days).

Eligibility

Sex/Gender

All

Age

18 Days to No maximum

Inclusion criteria

Inclusion criteria: All patients diagnosed with adhesive capusilits older than 18 years old

Exclusion criteria

Exclusion criteria: History of trauma Evidence of degenerative processes Active gastric ulcer History of GI bleeding History of hepatitis Patients with renal insufficiency Pregnant women

Design outcomes

Primary

Measure	Time frame
Passive range of motion of the involved shoulder (flexion, abduction, internal rotation, external rotation). Timepoint: Before intervention, and at 2, 4, and 8 weeks after intervention. Method of measurement: Analog Goniometer.;Perceived pain. Timepoint: Before intervention, and at 2, 4, and 8 weeks after intervention. Method of measurement: Visual Analog Scale.;Functional and disability outcomes. Timepoint: Before intervention, and at 2, 4, and 8 weeks after intervention. Method of measurement: Shoulder pain and disability index (SPADI) Questionnaire.	—

Measure

Time frame

Passive range of motion of the involved shoulder (flexion, abduction, internal rotation, external rotation). Timepoint: Before intervention, and at 2, 4, and 8 weeks after intervention. Method of measurement: Analog Goniometer.;Perceived pain. Timepoint: Before intervention, and at 2, 4, and 8 weeks after intervention. Method of measurement: Visual Analog Scale.;Functional and disability outcomes. Timepoint: Before intervention, and at 2, 4, and 8 weeks after intervention. Method of measurement: Shoulder pain and disability index (SPADI) Questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSina Owlia

Yazd University of Medical Sciences

sinowlia@gmail.com+98 35 3725 8410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026