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Evaluation of the combined effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on treatment, clinical symptoms of non-hospitalization and hospitalization patients with symptomatic COVID-19

effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on treatment, clinical symptoms of non-hospitalization and hospitalization patients with symptomatic COVID-19

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181030041504N1
Enrollment
100
Registered
2020-11-08
Start date
2020-10-07
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

covid-19. Severe Acute Respiratory Syndrome coronavirus

Interventions

Intervention 1: Intervention group: non-hospitalization patients with symptomatic COVID-19 received 1. Artemisia annua - Artemisinin ( Manufactured by Longlifenutri)150 mg every 24 hours 2. Dose of 1

Sponsors

Sirjan Faculty of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to No maximum

Inclusion criteria

Inclusion criteria: COVID-19 virus infection by RT-PCR in non-hospitalization and hospitalization patients G6PD sufficient in non-hospitalization and hospitalization patients Lack of clinical response to routine outpatient treatment in non-hospitalization and hospitalization patients Clinical symptoms (fever, cough, myalgia, shortness of breath, digestive problems) in non-hospitalization and hospitalization patients Age over 12 years in non-hospitalization and hospitalization patients Patient satisfaction in non-hospitalization and hospitalization patients Lymphocytes less than 15%, respiratory distress, lung involvement on CT scan, oxygen level less than 93%, unstable vital signs, severe gastrointestinal symptoms and oral intolerance, underlying disease Except for exclusion cases hospitalization patients

Exclusion criteria

Exclusion criteria: Allergy to oral supplements and high doses of vitamin C Reluctance to continue participating in the trial for any reason Patients admitted to the intensive care unit (ICU) (patients who have been admitted to the ICU since admission) Pregnant and lactating lady Patients with seizures Dialysis patients

Design outcomes

Primary

MeasureTime frame
LDH. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test.;CBC diff. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test.;Na/K/Ca. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test.;CRP. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test.;ESR1. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test.;Weakness and nausea. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Check List.;Lung involvement. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: CT-Scan.

Secondary

MeasureTime frame
Determination of the effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on on oxygen. Timepoint: 10 day. Method of measurement: Pulse Oximeter.;General condition of people and vitality after treatment. Timepoint: 10 day. Method of measurement: Examination and history.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Ali,Amjadi

Sirjan Faculty of Medical Science

Aamjadi50@yahoo.com+98 34 4234 0640

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026