Evaluation of pregnancy success in infertile people with low ovarian reserve and less than 35 years old in IVF method with two different protocols.

Evaluation of the pregnancy outcome in the GnRH antagonist protocol with pretreatment in the luteal phase (including oral estradiol with or without GnRH antagonist) in comparison with the microdose GnRH agonist protocol in poor responder patients (Poseidon 3) in patients undergoing fertility treatment at the Milad Infertility Center.(randomized clinical trial)

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181030041503N8

Enrollment

105

Registered

2023-11-13

Start date

2023-11-22

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Complications of attempted introduction of embryo in embryo transfer

Interventions

Intervention 1: Intervention group: In the first group, from the 19th day of the previous cycle, oral estradiol is prescribed at a dose of 4 mg daily for 10 days. Gonadotropins start on the third day

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Infertile women candidates for IVF under 35 years of age with regular cycles and low ovarian reserves (AMH<1.2 and AFC<5)

Exclusion criteria

Exclusion criteria: Male factor of infertility (severe), having moderate to severe endometriosis, having adenomyosis, or having uterine myoma other than subserous myoma with any syzymoma less than 4 cm, BMI>30

Design outcomes

Primary

Measure	Time frame
Total number of oocytes. Timepoint: Total number of M2 oocytes. Method of measurement: After picking up and laboratory examination.;Chemical pregnancy. Timepoint: n 2 week after embryo transfer. Method of measurement: BHCG.;The rate of clinical pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography.;Ongoing pregnancy. Timepoint: Continue pregnancy for up to 20 weeks. Method of measurement: Sonography.	—

Measure

Time frame

Total number of oocytes. Timepoint: Total number of M2 oocytes. Method of measurement: After picking up and laboratory examination.;Chemical pregnancy. Timepoint: n 2 week after embryo transfer. Method of measurement: BHCG.;The rate of clinical pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography.;Ongoing pregnancy. Timepoint: Continue pregnancy for up to 20 weeks. Method of measurement: Sonography.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactmalihe mahmoudinia

Mashhad University of Medical Sciences

mahmoudiniam@mums.ac.ir+98 51 3853 4021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026