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Effect of GnRH agonist and letrozole treatment in women with recurrent implantation failure

Comparison of pregnancy rate after frozen embryo transfer in two methods of endometrial preparation: using GnRH agonist together with letrozole and GnRH agonist alone in women with recurrent implantation failure

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181030041503N7
Enrollment
60
Registered
2023-11-02
Start date
2023-10-02
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Complications of attempted introduction of embryo in embryo transfer

Interventions

Intervention 1: Intervention group: In the intervention group, treatment with GnRH agonist, decapeptyl ampoule with a dose of 3.75 mg intramuscular (Varian Pharmed Pharmaceutical Company) along with l

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile women (18-40 years) with a history of at least two failed embryo transfers and at least 5 good-quality embryos have been transferred. Document of the normal uterine cavity normal test of TSH, Prolactin and thrombophilia lack of confirmed endometriosis and Endometrioma Lack of fibroma greater than 4 centimeters.

Exclusion criteria

Exclusion criteria: patient dissatisfaction during treatment to continue the study The presence of pathology endometrial

Design outcomes

Primary

MeasureTime frame
Chemical pregnancy rate. Timepoint: 2 week after embryo transfer. Method of measurement: BHCG.;The rate of clinical pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography.;Ongoing pregnancy. Timepoint: Continue pregnancy for up to 12 weeks. Method of measurement: Sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmalihe mahmoudinia

Mashhad University of Medical Sciences

mahmoudiniam@mums.ac.ir+98 51 3853 4021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026