Effect of intraovarian injection of platelet-rich plasma in women with poor ovarian response

Assessment of the effect of intraovarian platelet-rich plasma (PRP) injection on the results of assisted reproductive methods in infertile women with poor ovarian response (Poseidon 1, 2, 3,4)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181030041503N12

Enrollment

Registered

2026-01-01

Start date

2025-10-23

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility, unspecified

Interventions

Intervention 1: In the intervention group, 60 cc of blood is collected from each participant, and platelet-rich plasma with a concentration of 4-5 times baseline is prepared using the Royagen kit (app

Eligibility

Sex/Gender

Female

Age

21 Years to 42 Years

Inclusion criteria

Inclusion criteria: Women with poor ovarian response, which includes patients who had less than or equal to 4 oocytes retrieved in a previous IVF cycle Anti-Mullerian Hormone (AMH) less than 1.2 ng/mL Antral follicle count (AFC) less than 5 follicles in both ovaries on ultrasound on the third day of the period Regular menstruation every 24-35 days

Exclusion criteria

Exclusion criteria: Presence of severe endometriosis, grade 3 and 4. Presence of severe adenomyosis. Presence of a uterine anomaly. Presence of a chromosomal abnormality in the karyotype of either the woman or the man. A medical history that includes uncontrolled hypertension, thrombotic disease, or uncontrolled diabetes.

Design outcomes

Primary

Measure	Time frame
Ongoing Pregnancy Rate. Timepoint: At 12weeks after embryo transfer. Method of measurement: Ultrasound examination.;Miscarriage rate. Timepoint: Before 20 weeks of pregnancy. Method of measurement: Ultrasound examination.;Number of follicles developed. Timepoint: Trigger injection day. Method of measurement: Transvaginal ultrasound.;Total number of oocytes retrieved on the day of ovulation. Timepoint: On the day of Ovum Pick Up. Method of measurement: Examination by an embryologist.;Number of grade 1 and 2 embryos. Timepoint: 2-5 days after ovulation. Method of measurement: Examination by an embryologist.;Chemical pregnancy: positive ß-HCG test greater than 25 mIU/ml after 12–16 days from embryo transfer. Timepoint: 12–16 days after embryo transfer. Method of measurement: Serum ß-human chorionic gonadotropin (ß-hCG) measurement using quantitative immunoassay.;Clinical pregnancy rate. Timepoint: 6 weeks after transfer. Method of measurement: Ultrasound examination.	—

Measure

Time frame

Ongoing Pregnancy Rate. Timepoint: At 12weeks after embryo transfer. Method of measurement: Ultrasound examination.;Miscarriage rate. Timepoint: Before 20 weeks of pregnancy. Method of measurement: Ultrasound examination.;Number of follicles developed. Timepoint: Trigger injection day. Method of measurement: Transvaginal ultrasound.;Total number of oocytes retrieved on the day of ovulation. Timepoint: On the day of Ovum Pick Up. Method of measurement: Examination by an embryologist.;Number of grade 1 and 2 embryos. Timepoint: 2-5 days after ovulation. Method of measurement: Examination by an embryologist.;Chemical pregnancy: positive ß-HCG test greater than 25 mIU/ml after 12–16 days from embryo transfer. Timepoint: 12–16 days after embryo transfer. Method of measurement: Serum ß-human chorionic gonadotropin (ß-hCG) measurement using quantitative immunoassay.;Clinical pregnancy rate. Timepoint: 6 weeks after transfer. Method of measurement: Ultrasound examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMalihe Mahmoudinia

Mashhad University of Medical Sciences

mahmoudiniam@mums.ac.ir+98 915 304 7813

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026