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Investigating the Effect of Non-Absorbable Antibiotics Gavage on Sepsis Rates.

Investigating the Effect of Selective Digestive Decontamination with Non-Absorbable Antibiotics Before Percutaneous Endoscopic Gastrostomy (PEG) on the Incidence of Sepsis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181028041484N3
Enrollment
70
Registered
2025-02-14
Start date
2025-01-20
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis. Other sepsis

Interventions

Intervention 1: Intervention group: Patients are NPO for 12 hours before percutaneous endoscopic gastrostomy (PEG) placement. Four hours before transfer to the operating room, 100 cc of a solution con

Sponsors

Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Aged 18 to 75 years Vegetative state or minimally conscious syndrome Poor swallowing and determination of indication for percutaneous gastrostomy placement with the opinion of an intensivist

Exclusion criteria

Exclusion criteria: Fever Leukocytosis Signs of active pulmonary infection and sepsis Lack of consent from a legal guardian for the patient to participate in the study. Performing surgery on the gastrointestinal tract History of allergy to drugs used in the study

Design outcomes

Primary

MeasureTime frame
Percentage of people whose blood culture is positive and sepsis is confirmed. Timepoint: Before the intervention and once after it, in case of signs of infection such as fever and leukocytosis. Method of measurement: Collecting 5 cc of venous blood in a culture container and sending it to the laboratory for blood culture.;Local infection at the surgical site. Timepoint: Daily for up to three days after surgery. Method of measurement: Using a local surgical site infection assessment tool that examines erythema or inflammation of the catheter edge, catheter site induration, and the presence of exudate, which is scored between 0-4 based on the degree of erythema and induration and the amount of exudate.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Akbar Keykha

Zahedan University of Medical Sciences

aliakhbar.kheykha@zaums.ac.ir+98 34 4248 5032

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026