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Investigation of the Effects of Oral Caffeine and Medroxyprogesterone on Improving Respiratory Function

Comparing the Effects of Oral Caffeine and Medroxyprogesterone on Improving Respiratory Function in Traumatic Brain Injury Patients Under Mechanical Ventilation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181028041484N2
Enrollment
105
Registered
2024-11-07
Start date
2024-11-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury.

Interventions

Intervention 1: Intervention group: In the first intervention group, after the physical conditions were stable and the necessary surgeries were performed, on the fourth day of hospitalization in the i

Sponsors

Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 18 years old Mechanical ventilation through an endotracheal tube for at least 4 days Consciousness level based on GCS scale =5

Exclusion criteria

Exclusion criteria: Heart failure Renal failure Liver failure

Design outcomes

Primary

MeasureTime frame
Rapid shallow breathing index (RSBI). Timepoint: Before the start of the intervention and after the intervention daily until the successful weaning from the ventilator or a maximum of 10 days. Method of measurement: It is calculated by dividing the tidal volume by the respiratory rate. Its value is measured by the ventilator.;Number of spontaneous breathing. Timepoint: Before the start of the intervention and after the intervention daily until the successful weaning from the ventilator or a maximum of 10 days. Method of measurement: It is measured by the ventilator.;Volume of spontaneous breathing. Timepoint: Before the start of the intervention and after the intervention daily until the successful weaning from the ventilator or a maximum of 10 days. Method of measurement: It is measured by the ventilator.;Lung compliance. Timepoint: Before the start of the intervention and after the intervention daily until the successful weaning from the ventilator or a maximum of 10 days. Method of measurement: Lung compliance is calculated by dividing volume by pressure. Its value is measured by the ventilator.;Negative inspiratory force. Timepoint: Before the start of the intervention and after the intervention daily until the successful weaning from the ventilator or a maximum of 10 days. Method of measurement: It is measured by the ventilator.;Duration of mechanical ventilation. Timepoint: Time to separate the patient from the ventilator and extubation of patients. Method of measurement: Counting the number of days that patients were ventilated by a ventilator.;Success of weaning from mechanical ventilation. Timepoint: From the time of endotracheal tube removal to 48 hours later. Method of measurement: Patients who do not require re-intubation and mechanical ventilation until 48 hours after tracheal tube removal are considered successfully weaned from the ventilator.;Level of consciousness. Timepoint: Before the start of the intervention and after the intervention daily until

Secondary

MeasureTime frame
Duration of hospitalization in the intensive care unit. Timepoint: At the end of the study (when the patient was discharged from the intensive care unit). Method of measurement: Counting the number of days from the time of admission to the time of discharge of the patient from the intensive care unit.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAliakbar Keykha

Zahedan University of Medical Sciences

aliakbar.keykha@zaums.ac.ir+98 54 3344 2481

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026