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The comparison the effect of flaxseed and Conjugated Estrogen vaginal cream in vaginal atrophy and sexual satisfaction of postmenopausal women.

The comparison the effect of flaxseed and Conjugated Estrogen vaginal cream in vaginal atrophy and sexual satisfaction of postmenopausal women.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181027041473N1
Enrollment
70
Registered
2019-01-09
Start date
2018-11-22
Completion date
Unknown
Last updated
2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrophy and sexual satisfaction. Postmenopausal atrophic vaginitis

Interventions

Intervention 1: Control group: use conjugated estrogen vaginal cream for 8 weeks, so that the first two weeks every night, then twice a week until the end of the study period. Intervention 2: Interven

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Having a willingness to participated in the study Married and have sexual activity age range of 40-65 years Have literacy to read and write Amenorrhoea has been followed for at least 12 months or 6 months amenorrhoea with FSH> 40. Have normal Pap smear in the past 3 years Clinic diagnosis of vaginal atrophy through a set of criteria including: score 65 or more (based on the VAS visual criteria) of the scale of the most vaginal annoyance symptoms (MBS) and having at least 2 signs of the descriptive evaluation table of vaginal mucus, PH> 5 and VMV=55 (vaginal maturation grade).

Exclusion criteria

Exclusion criteria: Abnormal bleeding vaginal (pink to brown spotting or clear bleeding). have chronic illness such as diabetes, arthritis, cardiovascular disease, active liver disease or gallbladder disease. having vaginal infection allergy to estrogen or flax seed compounds don't suffering of endometrial cancer or breast cancer Endometrial cancer or breast cancer known or suspected . Consumer Products hormonal vaginal or transdermal than 4 weeks prior to the study and use of oral estrogen, uterine progesterone 8 weeks before the study and use of implants progesterone and estrogen injections for 3 months and pellets of estrogen and progesterone injections 6 months prior to the study to be

Design outcomes

Primary

MeasureTime frame
Atrophy and sexual satisfaction treatment. Timepoint: Performing the intervention then measuring vaginal atrophy and sexual satisfaction in the fourth and eighth weeks. Method of measurement: Using vaginal maturation index of more than 55 and a vaginal pH of more than 5 and gaining a score of 65 or more from the scale of the most vaginal annoying symptoms and having at least two signs of the symptoms of a descriptive evaluation table of vaginal mucus.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFahimeh shakeri

Mashhad University of Medical Sciences

Shakerif961@mums.ac.ir+98 51 3859 1511

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026