Investigation of the effect of trehalose on troponin and C-Reactive Protein in patients with myocardial infarction

Investigation of the effect of trehalose on troponin and CRP levels in patients with ST elevation myocardial infarction (STEMI)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181022041407N9

Enrollment

100

Registered

2024-08-19

Start date

2024-10-22

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: ST-elevation myocardial infarction. Condition 2: ST-elevation myocardial infarction. Condition 3: ST-elevation myocardial infarction. Condition 4: ST-elevation myocardial infarction. Condition 5: ST-elevation myocardial infarction. ST elevation (STEMI) myocardial infarction of anterior wall ST elevation (STEMI) myocardial infarction of inferior wall ST elevation (STEMI) myocardial infarction of other sites ST elevation (STEMI) myocardial infarction of unspecified site Acute myo

Interventions

Intervention 1: Intervention group: Trehalose 30 g before PCI, 30 g in the first 24hours after PCI. Then 10 g per day for 2 months, made by Shaanxi Fruiterco Biotechnology Co.,Ltd. Intervention 2: Con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with STEMI who refer to cath lab of Ghaem Hospital Only one artery needs revascularization after angiography (and no need for more revascularization in the next 2 months) Satisfaction for participation in research project.

Exclusion criteria

Exclusion criteria: Cardiogenic shock

Design outcomes

Primary

Measure	Time frame
High sensitive Troponin (hs-Troponin). Timepoint: Before PCI, then 1 and 2 days after PCI (2 times in the first 48 hours after PCI). Method of measurement: Blood test.;High sensitive C-reactive protein (hs-CRP). Timepoint: Before PCI, then 1 and 2 days after PCI (2 times in the first 48 hours after PCI). Method of measurement: Blood test.	—

Secondary

Measure	Time frame
Neutrophil to lymphocyte ratio (NLR). Timepoint: Before PCI, then 1 and 2 days after PCI. Method of measurement: Blood test.;Creatinine. Timepoint: Before PCI, then 1 and 2 days after PCI. Method of measurement: Blood test.;Ejection fraction (EF). Timepoint: Before PCR, before discharge, after 2 months. Method of measurement: Echocardiography.;Changes in electrocardiogram. Timepoint: Baseline, after performing PCI, 24 hours after PCI, after 2 months. Method of measurement: Electrocardiography.	—

Measure

Time frame

Neutrophil to lymphocyte ratio (NLR). Timepoint: Before PCI, then 1 and 2 days after PCI. Method of measurement: Blood test.;Creatinine. Timepoint: Before PCI, then 1 and 2 days after PCI. Method of measurement: Blood test.;Ejection fraction (EF). Timepoint: Before PCR, before discharge, after 2 months. Method of measurement: Echocardiography.;Changes in electrocardiogram. Timepoint: Baseline, after performing PCI, 24 hours after PCI, after 2 months. Method of measurement: Electrocardiography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Emadzadeh

Mashhad University of Medical Sciences

maryamemadzadeh@yahoo.com+98 51 3841 7403

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026