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The effect of trehalose on stroke

Investigation of the effect of trehalose on CRP, disability and complication of stroke in ischemic stroke patients: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181022041407N7
Enrollment
100
Registered
2024-08-06
Start date
2024-08-22
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke. Stroke, not specified as haemorrhage or infarction

Interventions

Intervention 1: Intervention group: Two packages each contains 30 gr trehalose in the first 24 hours, then one package (30 gr) daily till 5 days (or until discharge in case of discharge earlier than 5

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with ischemic stroke Age more than 18 years old Satisfaction for participation in research project (by the patient or his guardian). NISS score between 5-25 or less than 5 with aphasia, ataxia, or anopia.

Exclusion criteria

Exclusion criteria: Willingness to withdraw from the study Pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
C-reactive protein (CRP). Timepoint: Baseline and after 5 days (or at the time of discharge in case of discharge earlier than 5 days). Method of measurement: Blood test.;Modified Rankin Scale (MRS). Timepoint: Baseline and after 5 days (or at the time of discharge in case of discharge earlier than 5 days), after 1 and 3 months of intervention. Method of measurement: Checklist.;Complete Blood Count (CBC). Timepoint: Baseline and after 5 days (or at the time of discharge in case of discharge earlier than 5 days). Method of measurement: Blood test.;National Institutes of Health Stroke Scale (NIHSS). Timepoint: Baseline and after 5 days (or at the time of discharge in case of discharge earlier than 5 days). Method of measurement: Checklist and physical examination.

Secondary

MeasureTime frame
Assessment of stroke complication such as recurrent stroke, myocardial infarction (MI), transient ischemic attack (TIA), bleeding, mortality. Timepoint: Monthly for 3 months. Method of measurement: By asking questions from the patients.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Soltani

Mashhad University of Medical Sciences

soltani_sabi137@yahoo.com+98 51 3801 2398

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026