The effect of curcumin on metabolic syndrome in children

The effect of curcumin plus piperine on metabolic syndrome in children

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181022041407N4

Enrollment

Registered

2023-06-18

Start date

2023-07-23

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic syndrome. -

Interventions

Intervention 1: Intervention group: Curcumin tablet daily (contains 500 mg Curcumin and 5 mg Piperine) made by Sami-Sabinsa Group Limited for 90 days. Intervention 2: Control group: placebo (microcrys

Eligibility

Sex/Gender

All

Age

7 Years to 18 Years

Inclusion criteria

Inclusion criteria: Children aged 7-18 years Have metabolic syndrome Satisfaction for participation in research project

Exclusion criteria

Exclusion criteria: Suffering from cancer or chronic liver or kidney diseases Use of corticosteroids Oral intolerance to administered supplement Not satisfied with continuation of the study Allergy to turmeric / black pepper

Design outcomes

Primary

Measure	Time frame
Improvement of metabolic syndrome according to Cook`s definition. Timepoint: Baseline, after 3 months. Method of measurement: Measurement the components of metabolic syndrome according to Cook`s criteria includes: blood pressure with digital manometer and determine its percentile for children, use tape measure for waist circumference, blood sample to assess TG, HDL, FBS.;Anthropometric indices including height, weight, hip circumference, waist circumference, body mass index (BMI) and their related percentiles. Timepoint: Baseline, after 3 months. Method of measurement: Use tape measure for hip and waist circumferences and height, use a digital scale for measuring weight.;Total Cholestrol. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Low-density lipoprotein (LDL). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;High-density lipoprotein (HDL). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Fasting blood glucose. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Triglyceride. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Systolic and diastolic blood pressures and their related percentiles. Timepoint: Baseline, after 3 months. Method of measurement: Digital manometer.	—

Measure

Time frame

Improvement of metabolic syndrome according to Cook`s definition. Timepoint: Baseline, after 3 months. Method of measurement: Measurement the components of metabolic syndrome according to Cook`s criteria includes: blood pressure with digital manometer and determine its percentile for children, use tape measure for waist circumference, blood sample to assess TG, HDL, FBS.;Anthropometric indices including height, weight, hip circumference, waist circumference, body mass index (BMI) and their related percentiles. Timepoint: Baseline, after 3 months. Method of measurement: Use tape measure for hip and waist circumferences and height, use a digital scale for measuring weight.;Total Cholestrol. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Low-density lipoprotein (LDL). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;High-density lipoprotein (HDL). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Fasting blood glucose. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Triglyceride. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Systolic and diastolic blood pressures and their related percentiles. Timepoint: Baseline, after 3 months. Method of measurement: Digital manometer.

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Secondary

Measure	Time frame
Insulin. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Liver enzymes including aspartate aminotransferase (AST) and Alanine transaminase (ALT). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Hemoglobin A1c (HbA1C). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Timepoint: Baseline, after 3 months. Method of measurement: [glucose × insulin]/405.;Quantitative insulin sensitivity check index (QUICKI). Timepoint: Baseline, after 3 months. Method of measurement: 1 / [log (fasting insulin) + log (fasting glucose)].	—

Measure

Time frame

Insulin. Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Liver enzymes including aspartate aminotransferase (AST) and Alanine transaminase (ALT). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Hemoglobin A1c (HbA1C). Timepoint: Baseline, after 3 months. Method of measurement: Blood sample.;Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Timepoint: Baseline, after 3 months. Method of measurement: [glucose × insulin]/405.;Quantitative insulin sensitivity check index (QUICKI). Timepoint: Baseline, after 3 months. Method of measurement: 1 / [log (fasting insulin) + log (fasting glucose)].

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Emadzadeh

Mashhad University of Medical Sciences

maryamemadzadeh@yahoo.com+98 51 3841 7403

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026