Pre-acute ST-segment Elevation Myocardial Infarction (STEMI) Left Ventricular (LV) thrombosis. Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute myocardial infarction
Conditions
Interventions
Intervention 1: Intervention group: Rivaroxaban-based antithrombotic therapeutic regimen. Intervention 2: Control group: Warfarin-based antithrombotic therapeutic regimen.
Sponsors
Rajaie cardiovascular medical and research center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients with the age of 18-80 admitted with an acute STEMI Presence of LV thrombosis, which were confirmed by transthrocic echocardiography Signed informed consent
Exclusion criteria
Exclusion criteria: Previous history of mechanical prosthetic heart valve Candidate for coronary artery bypass graft surgery Active bleeding Cardiogenic shock Acute Kidney Injury or Chronic Kidney Disease with a glomerular filtration rate <30 ml/min Liver failure (Child-Pugh class C) Sensitivity or intolerance to rivaroxaban/warfarin/P2Y12 inhibitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of left ventricular thrombus. Timepoint: 3 months after initiation of antithrombotic therapeutic regimen. Method of measurement: Transthoracic echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding after initiation of antithrombotic regimen. Timepoint: 1 month and 3 months after initiation of antithrombotic regimen. Method of measurement: ISTH criteria. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParham Sadeghipour
Rajaie Cardiovascular Medical and Research Center
Outcome results
None listed