Thrombolytic in mechanical prosthetic valve thrombosis

Comparison of fast versus ultraslow infusion of thrombolytic in patients with mechanical prosthetic valve thrombosis- A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181022041406N2

Enrollment

120

Registered

2019-04-03

Start date

2018-07-23

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical prosthetic valve thrombosis. Mechanical complication of heart valve prosthesis

Interventions

Intervention 1: Intervention group: Fast thrombolytic regimen. Intervention 2: Intervention group: ultraslow thrombolytic regimen.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Provision of signed and dated informed consent form Patients with prosthetic mechanical valve thrombosis approved by echocardiography Men and women = 18 year-old

Exclusion criteria

Exclusion criteria: Contraindication of thrombolytic therapy Dyspnea of functional class 4 Thrombus size larger than 0.8 cm2

Design outcomes

Primary

Measure	Time frame
Degree of valve opening. Timepoint: Hospitalization. Method of measurement: Echocardiography.;Thrombus size. Timepoint: Hospitalization. Method of measurement: Echocardiography.;Clinical functional class. Timepoint: Hospitalization. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Bleeding. Timepoint: Hospitalization. Method of measurement: CT angiography.;Thromboembolic events. Timepoint: Hospitalization. Method of measurement: CT angiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParham Sadeghipour

Rajaie cardiovascular medical and research center

psadeghipour@rhc.ac.ir+98 21 2392 2092

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026