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Effect of rectal Misoprostol in reducing blood loss before hysterectomy and myomectomy

Effect of rectal Misoprostol in reducing blood loss before hysterectomy and myomectomy

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181020041394N1
Enrollment
80
Registered
2018-11-30
Start date
2018-06-13
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine lymphoma. benign neoplasms of uterus with morphology code M889 and behaviour code /0 fibromyoma of uterus

Interventions

Intervention 1: Intervention group: The first group received 400 micrograms of rectal misoprostol (200 micrograms, P.I.C., High Wycombe, England) 30 minutes before surgery. Intervention 2: Control gro

Sponsors

Babol University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 35 and 50 years The number of uterine fibroids is 5 or less The maximum size of the largest fiber is 3 cm All fibromas are subserosal or intramural in ultrasound Uterus size less than 24 weeks pregnant with two-handed examination if need for myomectomy

Exclusion criteria

Exclusion criteria: Any contraindication for using Misoprostol The presence of malignancy History of previous laparotomy except cesarean section History of endometriosis Cardiovascular and pulmonary diseases Bleeding disorders Hemoglobin below 10 g / dl Body mass index greater than 30 kg / m² Previous Myomectomy History History of using misoprostol with GnRH immediately before surgery Unwillingness to enter the study

Design outcomes

Primary

MeasureTime frame
Amount of bleeding during surgery. Timepoint: After the end of the surgery. Method of measurement: Volume of available hemorrhage in the suction device and the counting and calculation of blood gases.;Postoperative hemoglobin loss. Timepoint: Before surgery and 6 hours after surgery. Method of measurement: In grams per dL of the blood sample before surgery and 6 hours after surgery.

Secondary

MeasureTime frame
Complications after surgery. Timepoint: From the time of transfer to the department up to two weeks after the operation. Method of measurement: The incidence of complications is noted.;The incidence of complications during surgery. Timepoint: During surgery. Method of measurement: The incidence of complications is noted.;Length of the surgery. Timepoint: During surgery. Method of measurement: From the time of the initial entry of the laparoscopic tooth skinning to the skin in minutes.;Hemodynamic changes during surgery. Timepoint: During surgery. Method of measurement: The mean of vital signs registered during anesthesia by anesthesiologist is in mm of mercury (blood pressure), beats per minute (heart rate), centimeters (body temperature).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Azita Ghanbarpour

Babol University of Medical Sciences

a.ghanbarpour@mubabol.ac.ir+98 11 3225 6285

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026