Cystic Fibrosis. Cystic fibrosis
Conditions
Interventions
Intervention 1: Intervention group: Receiving standard treatment for cystic fibrosis plus one Lactobacilus reuterri sachet daily for 4 months. Intervention 2: Control group: Receiving standard treatm
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
6 Years to 20 Years
Inclusion criteria
Inclusion criteria: Patients who have been diagnosed with CF based on clinical signs and sweat Chloride test. No pulmonary exacerbation two weeks prior the study. Ability to perform spirometry test. The informed willingness to participate in the study. Presence of no other chronic disorder except complications related to CF Six to Twenty years old patients with Cystic Fibrosis disease. The Forced Expiratory Volume in 1 second (FEV1) greater than 40%. Stable clinical condition and no acute upper and lower respiratory infection.
Exclusion criteria
Exclusion criteria: Diagnosed as CF less than 6 months. New complication of CF during the past 3 months. No routine follow up. Disability to perform and repeat spirometry test according to American Thoracic Society criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary exacerbation frequency. Timepoint: During study period (4 months). Method of measurement: Observing symptoms of exacerbation in follow-up visits or patient statements.;Hospitalization frequency. Timepoint: During study period (4 months). Method of measurement: Patient statements.;Weight Z-score. Timepoint: At baseline and at the end of study. Method of measurement: Scale.;Height Z-score. Timepoint: At baseline and at the end of study. Method of measurement: Meter.;BMI Z-score. Timepoint: At baseline and at the end of study. Method of measurement: Weight(kg)/ Height(m)2.;FEV1 Forced Expiratory Volume in First Second. Timepoint: At baseline and at the end of study. Method of measurement: Spirometry.;FEF25-75 Exhale middle airflow. Timepoint: At baseline and at the end of study. Method of measurement: Spirometry.;FEV1/FVC proportion of a person's vital capacity that they are able to expire in the first second of forced expiration to the full, forced vital capacity. Timepoint: At baseline and at the end of study. Method of measurement: Spirometry.;Forced Vital Capacity (FVC). Timepoint: At baseline and at the end of study. Method of measurement: Spirometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyedeh Zalfa Modaresi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed