Crease blood pressure. Essential (primary) hypertension
Conditions
Interventions
Intervention 1: Intervention group 1: Intravenous Midazolam injection of 1 mg and placebo vitamin B tablets. Intervention 2: Intervention group 2: intravenous Midazolam injection of 1 mg and Captopril
Sponsors
Shahroud University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Systolic or diastolic blood pressure above 180 on 110 mm Hg age group is 18-18 years old Have the power to understand and sign a conscientious informed consent
Exclusion criteria
Exclusion criteria: Chronic renal failure Cardiovascular disease History of stroke History of myocardial infarction Benzodiazepines consumed in the last week Use of muscle relaxants such as baclofen or anti-anxiety drugs Other groups such as zoolpidum or baspirone Acute left heart failure Captopril susceptibility Sensitivity to midazolam Sensitivity to midazolam Pregnant and lactating women The occurrence of a critical condition, according to the doctor's opinion, requires the administration of a blood pressure lowering medication other than midazolam and captopril Patients with a difference between the two arms are more than 15 mm Hg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic or diastolic blood pressure. Timepoint: Blood pressure measurement at the beginning of the study and 10 minutes after (before the intervention). Then at 15, 30, 45 and 60 minutes after the intervention. Method of measurement: How to measure blood pressure in a standardized manner using a mercurial barometric device. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleepiness rate. Timepoint: 15, 30, 45 and 60 minutes after intervention. Method of measurement: Examination by a specialist.;Shortness of breath. Timepoint: 15, 30, 45 and 60 minutes after intervention. Method of measurement: Examination by a specialist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Reza Khorsand Kemachali
Shahroud University of Medical Sciences
Outcome results
None listed