Dry eye syndrome. Other disorders of lacrimal gland
Conditions
Interventions
Intervention 1: International group 1: 0.05% nano formulation Tacrolimus drop produced at the Abu Reyhan Pharmacy Company for one eye twice a day, One drop use in the lower conjunctiva for one month.
Sponsors
Birjand University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 78 Years
Inclusion criteria
Inclusion criteria: chronic symptoms of burning, foreign body sensation or itching in both eyes, blurring of vision, photo phobia,and pain daily need for artificial tears The ocular surface disease index (OSDI)=23 tear film break-up time (TBUT) value of 10s or lower Strip Meniscometry test (SM tube) = 10 mm Schirmer test value at 5 min of 10mm or lower
Exclusion criteria
Exclusion criteria: Sensitivity to tacrolimus Pregnancy or lactation Other systemic atopic diseases Previous eye surgery Any structural abnormalities (lid scarring, entropion, trichiasis, etc.) Any inflammation in the anterior chamber Glaucoma Use of other topical drugs, other than artificial tears Use of topical or systemic antibiotics or anti-inflammatory drugs before entering the study Contact lens punctual occlusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Light sensitivity. Timepoint: Before intervention and one month after treatment. Method of measurement: Ocular Surface Disease Index (OSDI).;Blurred vision. Timepoint: Before intervention and one month after treatment. Method of measurement: Ocular Surface Disease Index (OSDI).;Eye irritation. Timepoint: Before intervention and one month after treatment. Method of measurement: Ocular Surface Disease Index (OSDI).;Foreign body sensation. Timepoint: Before intervention and one month after treatment. Method of measurement: Ocular Surface Disease Index (OSDI).;Tear film break up time test (TBUT). Timepoint: Before intervention and one month after treatment. Method of measurement: In seconds, with a timer and slit lamp.;Production of tears. Timepoint: Before intervention and one month after treatment. Method of measurement: Schirmer's test in millimeters.;Tear volume measurement (SM Tube). Timepoint: Before intervention and one month after treatment. Method of measurement: The SM Tube strip is held in the lower lip for 5 seconds. After 5 seconds, the height of the absorbed tear of the blue column is measured. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMozhgan Ahrary
Birjand University of Medical Sciences
Outcome results
None listed