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Investigating the effect of levothyroxine therapy on sex hormone levels

Investigating the effect of levothyroxine therapy on sex hormone levels in women with subclinical Hypothyroidism.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181006041252N6
Enrollment
80
Registered
2019-01-23
Start date
2019-01-11
Completion date
Unknown
Last updated
2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism

Interventions

Intervention 1: Intervention group: Patients in this group are treated with levothyroxine for two months (50 micrograms daily and fasting 5 days a week) with the aim of Euthyroidism. Intervention 2: C

Sponsors

Sabzevar University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
17 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women aged 17-40 years with TSH above the maximum normal laboratory range and less than 10 and also T3, T4 normal.

Exclusion criteria

Exclusion criteria: Irregular ovarian cycles (irregular menstruation) Pregnancy, breastfeeding, hypothalamic amenorrhoea, known pituitary diseases, and early menopause. The history of ovarian surgery, polycystic ovary syndrome (PCOS), and the use of hormonal medications. History of levothyroxine tablets in the last two months. Dissatisfaction patients to participate in the study.

Design outcomes

Primary

MeasureTime frame
Determine the level of Estrogen. Timepoint: At the beginning of the study (before the intervention) and 2 months after starting the intervention. Method of measurement: Use of Luminescence quantitative and ELISA methods.;Determine the level of progesterone. Timepoint: At the beginning of the study (before the intervention) and 2 months after starting the intervention. Method of measurement: Use of Luminescence quantitative and ELISA methods.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Najmeh Rahimi

Sabzevar University of Medical Sciences

rahimy.najmeh@gmail.com+98 51 4401 8337

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026