Comparison of the effect of Cysteamine 5% cream with Tranexamic acid Mesotherapy on the severity of epidermal Melasma.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181006041252N2

Enrollment

Registered

2018-11-29

Start date

2018-10-29

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epidermal Melasma. Other epidermal thickening

Interventions

Intervention 1: Intervention group: Patients in this group use cysteamine 5% cream at night for 2 months, and also during a day they use a sunscreen with SPF 25% with zinc oxide 7.5% daily. Interventi

Eligibility

Sex/Gender

Female

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 50 years Patients who have been at least 6 months old since their illness Patients who have not received any medication for at least 2 months

Exclusion criteria

Exclusion criteria: History of Endocrine diseases, pregnancy and breast feeding Any Corticosteroids treatment 3 months before study Use of oral contraceptive pills before study Other skin diseases

Design outcomes

Primary

Measure	Time frame
Determine the severity of the area involved in Melasma. Timepoint: Week 4 and 8 after starting the intervention for Tranexamic acid and months 2 and 4 after the intervention for the Cysteamine group. Method of measurement: Based on Derma catch® score and MASI index (Melasma Area Severity Index).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Karrabi

Sabzevar University of Medical Sciences

Marikori90@gmail.com+98 51 4401 1604

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026