sesame anaphylaxis. Anaphylactic shock due to adverse food reaction
Conditions
Interventions
Intervention group:at first all patients receive two doses of omalizumaboral (anti IgE antibody)150 mg by subcutaneous injection 4 weeks before starting treatment and second dose at the begining of
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
4 Years to No maximum
Inclusion criteria
Inclusion criteria: positive oral food challenge with consumption of sesame tahini(OGHAB HALVA company) in patient with sesame anaphylaxis history with or without positive skin prick,skin prick to prick or specific IgE sesame tests
Exclusion criteria
Exclusion criteria: age less than 4 years history of cardiovascular disease beta blocker or ACEI drug usage severe or uncontrolled asthma infectious or immune deficiency disease unwillingness of patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sesame anaphylaxis in oral food challenge. Timepoint: ?Evaluation of sesame anaphylaxis in the begining of the study(before intervention) and 4 months after the end of immunotherapy. Method of measurement: oral food challenge test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum specific sesame immunoglobulin E level. Timepoint: in the begining of the study(before intervention) and 4 months after the end of immunotherapy. Method of measurement: ImmunoCAP specific IgE test.;Size of wheal in skin prick test. Timepoint: in the begining of the study(before intervention) and 4 months after the end of immunotherapy. Method of measurement: ruler.;Size of wheal in skin prick to prick test. Timepoint: in the begining of the study(before intervention) and 4 months after the end of immunotherapy. Method of measurement: ruler. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFereshteh Salari
Iran University of Medical Sciences
Outcome results
None listed