Assessment the effect of vitamin B6 supplementation on obesity and overweight

Assessment of the effect of oral pyridoxine hydrochloride supplement on anthropometric measurements, body composition, visceral adiposity index, glycemic and lipidemic risk factors and serum levels of leptin and adiponectin in obese and overweight women

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181002041206N1

Enrollment

Registered

2018-10-31

Start date

2018-10-12

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity and overweight. Overweight and obesity

Interventions

Intervention 1: Intervention group: pyridoxine hydrochloride Supplement, 2 pills 40 mg per day for 8 weeks. Intervention 2: Control group: Placebo, starch, 2 pills 40 mg per day for 8 weeks.

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Body mass index is over 25 kg / m2 No changes in weight over 5 kg over the past 3 months No history of diabetes, cardiovascular, brain, kidney, liver, respiratory, digestive, thyroid Do not use drugs that affect lipid profile and blood glucose and contraception Not taking any supplements including antioxidants, minerals, omega 3 and B6 within 2 months before the start of the study Non-use of cigarettes and alcohol Non-Lactation and Not pregnancy

Exclusion criteria

Exclusion criteria: Lack of patient collaboration at each stage of intervention Pregnancy during intervention Identify any of the diseases or use the drugs mentioned in the criteria for entry Start a weight loss diet

Design outcomes

Primary

Measure	Time frame
Body composition. Timepoint: The beginning and end of the study. Method of measurement: Body Composition Analyser.;Visceral Fat. Timepoint: The beginning and end of the study. Method of measurement: Calculation.;Blood Glucose. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Plasma Insulin. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Insulin resistance. Timepoint: The beginning and end of the study. Method of measurement: Calculation.;Total Cholesterol. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Triglycerides. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;HDL Cholesterol. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;LDL Cholesterol. Timepoint: The beginning and end of the study. Method of measurement: Calculation.;Leptin. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Adiponectin. Timepoint: The beginning and end of the study. Method of measurement: Blood test.	—

Measure

Time frame

Body composition. Timepoint: The beginning and end of the study. Method of measurement: Body Composition Analyser.;Visceral Fat. Timepoint: The beginning and end of the study. Method of measurement: Calculation.;Blood Glucose. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Plasma Insulin. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Insulin resistance. Timepoint: The beginning and end of the study. Method of measurement: Calculation.;Total Cholesterol. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Triglycerides. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;HDL Cholesterol. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;LDL Cholesterol. Timepoint: The beginning and end of the study. Method of measurement: Calculation.;Leptin. Timepoint: The beginning and end of the study. Method of measurement: Blood test.;Adiponectin. Timepoint: The beginning and end of the study. Method of measurement: Blood test.

—

Secondary

Measure	Time frame
Body Mass Index. Timepoint: The beginning and end of the study. Method of measurement: body weight / hight square (kg/m2).;Waist Circumference. Timepoint: The beginning and end of the study. Method of measurement: measurment.;Hip circumference. Timepoint: The beginning and end of the study. Method of measurement: measurment.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Mirzaey

Ahvaz University of Medical Sciences

mirzaey.f@ajums.ac.ir+98 61 3373 8383

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 16, 2026