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Antiemetic effect of Dexamethasone in pediatric endosocopy

Effectiveness of intravenous Dexamethasone on the incidence of nausea and vomiting after deep sedation, in upper GI endoscopy in pediatric patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180929041173N1
Enrollment
98
Registered
2018-10-26
Start date
2018-11-03
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post endoscopy nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Intervention group: After anesthesia is induced and deepened, 0/1 mg/(kg of body weight) of Dexamethasone is administered to patients intravenously. Intervention 2: Control group: Afte

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Years to 14 Years

Inclusion criteria

Inclusion criteria: All 2 to 14 year-old children, candidate for an elective upper GI endoscopy, according to the pediatric gastroenterologist diagnosis

Exclusion criteria

Exclusion criteria: Patients with a history of hypersensitivity to the drugs studied Patients with a history of metabolic disease or diabetes Patients with anatomical upper airway disorders Patients diagnosed with behavioral disorders or currently taking psychiatric medication Patients with a history of undergoing chemotherapy Patients who have taken a sedative/hypnotic drug prior to endoscopy Patients who are a candidate for an emergency endoscopy Patients whose operation is complicated (e.g. by bleeding) and takes too long to be completed Patients without a parental informed consent

Design outcomes

Primary

MeasureTime frame
Incidence of nausea/vomiting. Timepoint: Recording the incidence of nausea/vomiting, evaluated during patients' stay in the post-anesthesia recovery room. Method of measurement: Investigator evaluation and examination.

Secondary

MeasureTime frame
Post anesthesia emergence delirium. Timepoint: Recording the highest score of patients on PAED sacle, during their stay in the post-anesthesia recovery room. Method of measurement: Pediatric Anesthesia Emergence Delirium (PAED) Scale.;Incidence of bronchospasm/laryngospasm. Timepoint: Recording the incidence bronchospasm/laryngospasm, evaluated during patients' stay in the post-anesthesia recovery room. Method of measurement: Investigator evaluation and examination.;Time needed for patient recovery after endoscopy. Timepoint: Recording the time of patients stay in the post-anesthesia recovery room after endoscopy. Method of measurement: Subtracting the recorded time of entry to the recovery room, from the time the patient is eligible for transfer to the secondary recovery facilities.;Patients recovery state. Timepoint: Patients score on the Modified Aldrete scale is calculated and recorded at the time of entry to post-anesthesia recovery room, 5 minutes after entry, and at the time of discharge. Method of measurement: Modified Aldrete scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Moheimani

Tehran University of Medical Sciences

h-moheimani@alumnus.tums.ac.ir+98 21 81631

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026