Effect of vitamin E on Prevention of oral inflammation

Effect of vitamin E on prevention of oral mucositis in patients undergoing head and neck radiotherapy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180924041119N1

Enrollment

Registered

2018-10-12

Start date

2018-08-23

Completion date

Unknown

Last updated

2018-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of oral mucositis caused by head and neck radiotherapy.

Interventions

Intervention 1: Intervention group: Vitamin E, a daily dose of 200 mg, manufactured by the Dana Pharmaceutical Company,it is prescribed from first session of radiotherapy to 8 weeks. Intervention 2: C

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who have a radiotherapy indication of at least 50Gy throughout the study At least two areas in the radiotherapy field from mouth are involved the tumor

Exclusion criteria

Exclusion criteria: Patients with diabetes Patients with Candidiasis Patients who use tobacco.

Design outcomes

Primary

Measure	Time frame
Percentage of Vitamin E Preventional Effects on Oral Mucositis. Timepoint: At the beginning of the study (before the intervention) and 7, 14, 21, 28, 35, 42, 49 and 56 days after the start of taking the drug and placebo. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArash Azizi

Islamic Azad University

drarashazizi@yahoo.com+98 21 2258 0925

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026