Preventive Effect of induced muscle ischemia on acute kidney injury

Evaluation of induced muscle ischemia on prevention of acute kidney injury based on serum cystatin-c in admitted patients undergoing coronary angiography

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180924041113N1

Enrollment

140

Registered

2018-10-30

Start date

2017-11-06

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal dysfunction. Acute kidney failure

Interventions

Intervention 1: Intervention group: Remote Ischemic Preconditioning (RIPC) performed via the automated delivery of three cycles of 200 mm Hg blood pressure cuff inflation for 5 min followed by cuff de

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age equal to or greater than 18 years Hospitalized patients requiring angiography Patients who don’t use nephrotoxic drugs 72 hours before angiography Ejection fraction (EF) > 50% Patients without cardiogenic shock or recent cardiac infarction

Exclusion criteria

Exclusion criteria: Patients who did not have consent to participate in the study Patients with renal dysfunction (glomerular filtration rate (GFR) <60) based on KDIGO criteria Pregnant women Patients needing an emergency angiography

Design outcomes

Primary

Measure	Time frame
Serum Creatinine. Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: AutoAnalyzer.;Serum Cystatin-C. Timepoint: Before intervention and 24 hours after intervention. Method of measurement: The enzyme-linked immunosorbent assay (ELISA) kit.;Estimated glomerular filtration rate (eGFR). Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: Glomerular filtration rate Equation.;Acute Kidney Injury (AKI). Timepoint: After intervention daily for 2 days. Method of measurement: The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) criteria.	—

Measure

Time frame

Serum Creatinine. Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: AutoAnalyzer.;Serum Cystatin-C. Timepoint: Before intervention and 24 hours after intervention. Method of measurement: The enzyme-linked immunosorbent assay (ELISA) kit.;Estimated glomerular filtration rate (eGFR). Timepoint: Before intervention and after intervention daily for 2 days. Method of measurement: Glomerular filtration rate Equation.;Acute Kidney Injury (AKI). Timepoint: After intervention daily for 2 days. Method of measurement: The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) criteria.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzadeh Moradkhani

Bandare-abbas University of Medical Sciences

azadeh.moradkhani@yahoo.com+98 76 3375 4950

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026