To investigate the effect of music therapy on oxidative stress index and hemodynamic parameters in patients admitted to intensive care units

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180923041101N6

Enrollment

Registered

2025-08-18

Start date

2025-09-10

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients admitted to intensive care units. Glasgow coma scale score 3-8

Interventions

Intervention 1: Intervention group: Patients assigned to the intervention group will receive music therapy twice daily at predetermined times. After two days, blood samples will be collected from all

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Glasgow Coma Scale score between 3 and 8 Heart rate below 130 beats per minute and systolic blood pressure above 90 mmHg Age between 18 and 80 years

Exclusion criteria

Exclusion criteria: hearing impairments use of vitamin supplements or antioxidants history of head surgery presence of neurogenic diseases presence of autoimmune diseases history of cardiac or valvular disease, carotid artery disease, aortic aneurysm, right heart enlargement, pulmonary hypertension, or elevated central venous pressure

Design outcomes

Primary

Measure	Time frame
Malondialdehyde as an indicator of oxidative stress in the blood. Timepoint: Before music therapy and two-days after music therapy. Method of measurement: Take a patient blood sample and check with a malondialdehyde kit.;Systolic blood pressure, diastolic blood pressure, mean arterial pressure, respiratory rate, and heart rate as an indicator of hemodynamic parameters. Timepoint: Before music therapy and two-days after music therapy. Method of measurement: Blood pressure will be measured with an aneroid sphygmomanometer (Accumed model KJ-106) equipped with an appropriately sized cuff (24–32 cm) and a single-head stethoscope from the same manufacturer. Calibration of the device will be verified by biomedical engineers. Heart rate will be determined by counting the radial pulse for one full minute using a stopwatch by a single researcher. Respiratory rate will also be recorded over one minute by the researcher.	—

Measure

Time frame

Malondialdehyde as an indicator of oxidative stress in the blood. Timepoint: Before music therapy and two-days after music therapy. Method of measurement: Take a patient blood sample and check with a malondialdehyde kit.;Systolic blood pressure, diastolic blood pressure, mean arterial pressure, respiratory rate, and heart rate as an indicator of hemodynamic parameters. Timepoint: Before music therapy and two-days after music therapy. Method of measurement: Blood pressure will be measured with an aneroid sphygmomanometer (Accumed model KJ-106) equipped with an appropriately sized cuff (24–32 cm) and a single-head stethoscope from the same manufacturer. Calibration of the device will be verified by biomedical engineers. Heart rate will be determined by counting the radial pulse for one full minute using a stopwatch by a single researcher. Respiratory rate will also be recorded over one minute by the researcher.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Nazemifar

Shiraz University of Medical Sciences

maryamnazemifar@gmail.com+98 71 3823 3693

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026