Adriamycin induced oral mucositis. Oral mucositis (ulcerative) due to antineoplastic therapy
Conditions
Interventions
Intervention 1: Intervention group: A mixture of (500 ml ispaghula husk and 3 drops of vinegar in 30 cc water) should be kept in the mouth for 1 minute then poured out, three times a day . For 14 days
Sponsors
Vice chancellor for research, Kerman university of medical sciences
Eligibility
Sex/Gender
All
Age
17 Years to 65 Years
Inclusion criteria
Inclusion criteria: Breast cancer Candidate for adriamycin mucositis in screening course Remaining two courses of adriamycin with two weeks interval Age between 17 and 65 years Life expectancy for more than a year based on physician or team estimates Physical and mental ability to cooperate in filling in the questionnaire The desire to participate in the study
Exclusion criteria
Exclusion criteria: Use alcohol Use of drugs that affect salivary glands such as antipsychotics, opioids, antihypertensives, antihistamine, diuretics Use of mouthwashes and artificial saliva and cigarettes Receiving Early Radiation in mouth or oropharynx The history of connective tissue diseases, such as Sjogren, rheumatoid arthritis, lupus Liver and kidney disease Major Depression Diseases that affect salivary glands such as diabetes Diseases that induce dehydration such as chronic diarrhea Diseases of the immune system Recurrent aphthous stomatitis Receiving Lithium or Levothyroxine for interference with spaghula
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of oral mucositis according to WHO scale. Timepoint: Precisely before the intervention, 7 days after the start of intervention and 14 days after the start of intervention (the last day of the intervention). Method of measurement: WHO scale for oral mucositis.;Degree of pain due to oral mucositis. Timepoint: Precisely before the intervention, 7 days after the start of intervention and 14 days after the start of intervention (the last day of the intervention). Method of measurement: Visual Analogue Scale.;Quality of life. Timepoint: Precisely before the intervention, 7 days after the start of intervention and 14 days after the start of intervention (the last day of the intervention). Method of measurement: OHIP-14 questionnaire.;Xerostomia. Timepoint: Precisely before the intervention, 7 days after the start of intervention and 14 days after the start of intervention (the last day of the intervention). Method of measurement: LENT-SOMA scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Sadat Hasheminasab
Kerman University of Medical Sciences
Outcome results
None listed