Diabetic retinopathy. Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy
Conditions
Interventions
Intervention 1: Intervention group: Patients with type 2 diabetes who are at least 35 years of age who are referred to an internal clinic or family physician are referred to an ophthalmologist for ann
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: Age of at least 35 years Patients with type 2 diabetes who are treated with insulin or combined therapy (insulin with antidiabetic pill) They have NPDRP without the need for specific ophthalmologic treatment interventions HbA1C levels below 8% Systolic blood pressure up to 130 Diastolic blood pressure is up to 80 mmHg Normal GFR is proportional to age based on MDRD formula The amount of 24-hour urine albumin is less than 300 milligrams.
Exclusion criteria
Exclusion criteria: The history of any ocular disease (glaucoma, hypertensive retinopathy and cataract), or the history of eye surgery, or previous intra-ocular injections or visual acuity less than 6/10 History of chronic disease such as sarcoidosis, hyperparathyroidism and seizure, bone cancer or lung and liver cirrhosis and... History of bariatric surgery or absorption disorders or any other disease indicating vitamin D intake. History of kidney stones Pregnancy and lactation History of taking phenofibrate, thiazolidinedione, anticonvulsants, or drugs that interfere with the metabolism of vitamin D or produce eye effects, including macular edema. The history of severe psychiatric illnesses such as schizophrenia, mood disorders, borderline disorders. Regular supplementation of D supplementation in the last three months or during the study (in the control group) History of any drug allergy or side effects. Participants are reluctant to take drugs or placebo Participate in another research project over the past 3 months HbA1C levels of 8% and more Glucocorticoid intake in the last 3 months BMI more than 35 The amount of 24-hour urine albumin exceeds 300 milligrams The GFR is greater than the normal range based on the age-appropriate MDRD formula.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diabetic retinopathy. Timepoint: Start studying, 3months later, 6months later. Method of measurement: ETDRS scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index. Timepoint: Start studying, 6 months later. Method of measurement: measurement.;HA1C test. Timepoint: Start studying, 6 months later. Method of measurement: Laboratory measurement.;Macular thickness. Timepoint: Start studying, 6 months later. Method of measurement: OCT. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbolfazl Zendehdel
Tehran University of Medical Sciences
Outcome results
None listed