Effects of nitroglycerine (TNG) in intravenous pain control pump

Effects of adding trinitroglycerin (TNG) to the patient controlled intravenous analgesia pump in patients with lower limb orthopedic surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180922041088N1

Enrollment

Registered

2018-12-28

Start date

2017-09-01

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain control after surgery. Pain in limb, hand, foot, fingers and toes

Interventions

Intervention 1: First intervention group: Patients will use 500 microgram (mcg) Trinitroglycerin (TNG)-containing pain pump to reduce pain after lower limb orthopedic surgery. (Nitral, Caspian Tamin

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Lower extremities orthopedic patients Spinal anesthesia with 15 milligram (mg) bupivacain 0.5% Patients with American Society of Anesthesiologists (ASA) I,II

Exclusion criteria

Exclusion criteria: Addiction to alcohol, benzodiazepines and opium. Heart failure Patients dissatisfaction Allergies to any of used drugs Seizure Valvular heart disease Arrhythmia

Design outcomes

Primary

Measure	Time frame
Pain after lower limb orthopedic surgery. Timepoint: 4, 8, 12 and 24 hours after surgery. Method of measurement: Using Visual Analogue Scale.	—

Secondary

Measure	Time frame
Complications. Timepoint: During 24 hours after surgery. Method of measurement: With physical examination.;Need for adjuvant analgesic. Timepoint: During 24 hours using pain pump. Method of measurement: Using questionnaire information.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPoupak Rahimzadeh

Iran University of Medical Sciences

p-rahimzadeh@tums.ac.ir+98 21 8670 2503

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026