The effects of dexmedetomidine on post-operative blood glucose level in non diabetic patients undergoing cardiac surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180922041084N5

Enrollment

Registered

2022-01-05

Start date

2021-09-12

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Arteria Bypass Graft. Presence of aortocoronary bypass graft

Interventions

Intervention 1: Intervention group: Intervention group or group (dexmedetomidine (D)): In this group, continuous injection of dexmedetomidine made by ExIR Company at a dose of 0.5 µ g / kg/hr. It is i

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: The Patients are Candidates for Coronary Artery Surgery (CABG). No history of diabetes. The patients 40 to 80 years of age Receive informed written consent EF more than 40%.

Exclusion criteria

Exclusion criteria: emergency surgery valvular heart disease liver and kidney dysfunction take steroids History of drug sensitivity heart failure Acute Myocardial Infarction

Design outcomes

Primary

Measure	Time frame
Blood Glucose. Timepoint: Blood sugar before, during, and after surgery. Before induction of anesthesia, 15 minutes after induction of anesthesia, before the start of the cardiopulmonary pump, 30 minutes after the start of the cardiopulmonary pump, time of transfer to ICU 6 hours after transfer to ICU, 12 hours after transfer to ICU, and 24 hours after transfer to ICU. Method of measurement: Check Blood glucose by glucometer.	—

Measure

Time frame

Blood Glucose. Timepoint: Blood sugar before, during, and after surgery. Before induction of anesthesia, 15 minutes after induction of anesthesia, before the start of the cardiopulmonary pump, 30 minutes after the start of the cardiopulmonary pump, time of transfer to ICU 6 hours after transfer to ICU, 12 hours after transfer to ICU, and 24 hours after transfer to ICU. Method of measurement: Check Blood glucose by glucometer.

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Secondary

Measure	Time frame
Blood Potassium. Timepoint: Before induction of anesthesia (T0), 15 minutes after induction of anesthesia (T1), before the start of the cardiopulmonary pump (T2), 30 minutes after the start of the cardiopulmonary pump (T3), transfer time to ICU(T4), 6 hours after transfer to ICU (T5), 12 hours after transfer to ICU (T6), 24 hours after ICU transfer (T7). Method of measurement: By blood gas.;Check Heart rate. Timepoint: Before induction of anesthesia (T0), 15 minutes after induction of anesthesia (T1), before the start of the cardiopulmonary pump (T2), 30 minutes after the start of the cardiopulmonary pump (T3), transfer time to ICU(T4), 6 hours after transfer to ICU (T5), 12 hours after transfer to ICU (T6), 24 hours after ICU transfer (T7). Method of measurement: By heart monitoring.;Mean Arterial blood pressure. Timepoint: transfer time to ICU(T4), 6 hours after transfer to ICU (T5), 12 hours after transfer to ICU (T6), 24 hours after ICU transfer (T7). Method of measurement: Invasive arterial blood pressure monitoring.	—

Measure

Time frame

Blood Potassium. Timepoint: Before induction of anesthesia (T0), 15 minutes after induction of anesthesia (T1), before the start of the cardiopulmonary pump (T2), 30 minutes after the start of the cardiopulmonary pump (T3), transfer time to ICU(T4), 6 hours after transfer to ICU (T5), 12 hours after transfer to ICU (T6), 24 hours after ICU transfer (T7). Method of measurement: By blood gas.;Check Heart rate. Timepoint: Before induction of anesthesia (T0), 15 minutes after induction of anesthesia (T1), before the start of the cardiopulmonary pump (T2), 30 minutes after the start of the cardiopulmonary pump (T3), transfer time to ICU(T4), 6 hours after transfer to ICU (T5), 12 hours after transfer to ICU (T6), 24 hours after ICU transfer (T7). Method of measurement: By heart monitoring.;Mean Arterial blood pressure. Timepoint: transfer time to ICU(T4), 6 hours after transfer to ICU (T5), 12 hours after transfer to ICU (T6), 24 hours after ICU transfer (T7). Method of measurement: Invasive arterial blood pressure monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhosein Hasanzade

Shiraz University of Medical Sciences

A.hsanzade1367@gmail.com+98 71 3630 4312

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026