Radiotherapy of soft tissue sarcoma

The comparison of the preoperative radiotherapy with postoperative radiotherapy in patients with soft tissue sarcoma of the extremity referred to Firoozgar Hospital during 2017 to 2019

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180919041070N3

Enrollment

Registered

2020-01-12

Start date

2019-12-18

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant neoplasm of connective and soft tissue. Malignant neoplasm of connective and soft tissue, unspecified

Interventions

Intervention 1: Intervention group 1

Preoperative Radiotherapy: Patients first will receive radiation therapy at a mean dose of 50 Gy between 4 and 6 weeks and then undergo limb preservation surgery. Intervention 2: Intervention group 2

Postoperative Radiotherapy: Patients first will undergo limb preservation surgery by an orthopedic surgeon and receive radiation therapy with 60-66 Gy after surgical wound healing.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Pathologically confirmed localized soft tissue sarcoma of the extremity Age = 18 years Performance status < 2

Exclusion criteria

Exclusion criteria: Distant metastasis Pregnancy History of connective tissue diseases

Design outcomes

Primary

Measure	Time frame
Survival. Timepoint: 12 months after treatment. Method of measurement: visiting the patient.;Recurrence. Timepoint: 1, 6, and 12 months after treatment. Method of measurement: Taking history and physical exam.;Limb function. Timepoint: 1, 6, and 12 months after treatment. Method of measurement: physical exam.	—

Secondary

Measure	Time frame
Complications. Timepoint: 1, 6, and 12 months after treatment. Method of measurement: Physical exam.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamideh Mahmoudi

Iran University of Medical Sciences

research@iums.ac.ir+98 21 8214 1201

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026