Breast cancer. Malignant neoplasm of breast
Conditions
Interventions
Intervention 1: Intervention group: In hypofractionated radiotherapy group, during breast conservation surgery, patients will receive intraoperative electron radiation therapy with 10 gray dose. Posto
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: Definitive diagnosis of breast cancer on pathological examination Age more than 35 year old Tumor size equal and less than 5 centimeter No regional nodal involvement or involvement of equal and less than 3 nodes in post surgical pathological examination Clear surgical margin in post surgical pathological examination
Exclusion criteria
Exclusion criteria: Presence of in-situ carcinoma without invasive component Tumoral adhesion to muscles of the chest wall Inflammatory carcinoma karnofsky performance status less than 70% Previous history of the chest wall irradiation Multiple tumoral masses with more than 5 centimeter distance A history of connective tissue diseases including lupus disease and scleroderma Previous chronic pulmonary disease including pulmonary fibrosis, grade III chronic obstructive pulmonary disease and asthma Distant metastasis large breast based on planning target volume in radiotherapy more than 2500 mililiter Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin complication of radiotherapy. Timepoint: After the third week of radiotherapy and one year after the completion of radiotherapy. Method of measurement: National Cancer Institute Common Terminology Criteria for Adverse Events version 2.0.;Cosmotic outcome. Timepoint: [ne year after the completion of radiotherapy. Method of measurement: Objective Measurement of Cosmetic Outcomes. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPedram Fadavi
Iran University of Medical Sciences
Outcome results
None listed