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The effect of antibiotic therapy on the results of biopsy in men

The effect of antibiotic therapy on the results of biopsy in asymptomatic men older than 40 years of age with PSA above 4 ng/ml

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180915041037N1
Enrollment
80
Registered
2018-11-11
Start date
2018-10-23
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate Cancer. Malignant neoplasm of prostate

Interventions

Intervention 1: Intervention group: Patients will undergo antibiotic therapy (Ciprofloxacin tablets 500 mg every 12 hours for 4 weeks). Intervention 2: Control group: Patients won't undergo any medica

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients older than 40 years of age with prostate-specific antigen (PSA) in the range of 4-15 ng/ml Patients with normal digital rectal examination (DRE) Patients without Irritative and obstructive urinary symptoms Patients with informed consent

Exclusion criteria

Exclusion criteria: Patients undergoing rectal biopsy (TRUS) during the past month. Patients who have ejaculation in the past 28 hours. Patients who have undergone urological surgeries during the past six months. Patients with a history of prostate cancer or clinical and laboratory evidence Patients with a history of taking 5-alpha-blockers such as Finasteride in the past six weeks

Design outcomes

Secondary

MeasureTime frame
Biopsy results. Timepoint: One month after referring to the specialist. Method of measurement: Standard biopsy (12-core).

Primary

MeasureTime frame
PSA levels above 4 ng / ml. Timepoint: One month after referring to the specialist. Method of measurement: Blood test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHadi Maleki

Yazd University of Medical Sciences

hadi.maleki88@gmail.com+98 35 3626 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026