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Effect of Xylitol Varnish in Caries Prevention Around Orthodontic Brackets

Evaluation the Preventive Effect of Two Concentration of Xylitol Varnish vs Fluoride Varnish on Enamel Demineralization Around Orthodontic Brackets: A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180913041032N1
Enrollment
120
Registered
2018-10-14
Start date
2018-09-13
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Demineralization around Orthodontic brackets..

Interventions

Intervention 1: Intervention group 1: Xylitol varnish 10%. Intervention 2: Intervention group 2: Xylitol varnish 20 %. Intervention 3: Intervention group 3: Sodium fluoride varnish 5%. Intervention 4

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
13 Years to 17 Years

Inclusion criteria

Inclusion criteria: Patients with Class I malocclusion and complete permanent dentition up to the first molars. Good overall health and good oral hygiene (full mouth plaque score 1.0 mL/min) and buffer capacity (final pH between 6.0 and 7.0).

Exclusion criteria

Exclusion criteria: History of previous orthodontic treatment or extractions, bleaching or topical fluoridation. Severe crowding >6 mm, severely rotated teeth. Visible sign of caries, fluorosis, hypocalcification or developmental defects. Dental crowns, amalgam or composite filling which extended to the buccal surface. Systemic or endocrine condition (such as cardiac pacemakers or diabetes mellitus). Craniofacial anomalies and clefts Smokers.

Design outcomes

Primary

MeasureTime frame
Mean Diagnodent number. Timepoint: Before starting intervention, 3 and 6 months later and at the end of orthodontic treatment. Method of measurement: Diagnodent pen 2190.

Secondary

MeasureTime frame
Visual assessment of white spot lesions. Timepoint: At the end of orthodontic treatment. Method of measurement: With the Gorelick index.;Assessment of patients satisfaction of varnish therapy. Timepoint: After varnish therapy for patient. Method of measurement: Satisfaction questionnaire with binary (Yes/No) design.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMojgan Shavakhi

Shiraz University of Medical Sciences

shavakhi.m@gmail.com+98 71 3625 7449

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 15, 2026