Patients candidate for coronary artery bypass graft surgery. Unspecified complication of cardiac and vascular prosthetic device, implant and graft
Conditions
Interventions
Intervention 1: Intervention group: In group 1, melatonin at a dose of 3 mg, the night before surgery (9 pm) and the morning of surgery (6 am) and every night (9 pm) for 48 hours after surgery. In the
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Candidate for coronary artery bypass graft surgery with cardiopulmonary pump No allergy to melatonin and dexmedetomidine Elective surgery Age 40 to 75 years
Exclusion criteria
Exclusion criteria: Conscious dissatisfaction Emergency surgery Chronic use of melatonin or hypnotic drugs History of liver or kidney disease or chronic lung disease History of neurological or psychological diseases Ejection Fraction < 30%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium incidence. Timepoint: First day and second day after extubation. Method of measurement: Based on Confusion Assessment Method for the ICU.;Severity of delirium. Timepoint: First day and second day after extubation. Method of measurement: Based on Confusion Assessment Method for the ICU. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation duration. Timepoint: 6,8,10,12 ,24 hours after surgery. Method of measurement: Hour.;Duration of ICU staying. Timepoint: 2,3,4 days after surgery. Method of measurement: Day. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Javaherforoosh zadeh
Ahvaz University of Medical Sciences
Outcome results
None listed