Evaluation of the effect of orthokine on histological and radiographic characteristics of hard tissue after Horizontal Bone Augmentation and Socket Preservation surgery

The effect of Aoutologus Conditioned Serum on histological and radiographic characteristics of hard tissue after Horizontal Bone Augmentation and Socket Preservation surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180905040955N2

Enrollment

Registered

2022-01-09

Start date

2021-08-23

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Horizontal Bone Augmentation. Condition 2: Socket preservation.

Interventions

Intervention 1: Intervention group: According to the goal, 21 people will be studied to prove the hypothesis and achieve the desired goal. After preparing the volunteer patient psychologically and exp

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The difficulty of surgery is the same compared to the other side based on the dimensions required for augmentation as well as the condition of the existing tooth before extraction and the condition of the ridge. Patients should require implant placement in site patients should be satisfied for surgery.

Exclusion criteria

Exclusion criteria: presence of systemic diseases presence of history of using disruptive drugs in healing processes The patient does not want to have surgery Presence of metabolic bone diseases

Design outcomes

Primary

Measure	Time frame
The amount of collagen. Timepoint: 4 months after surgery. Method of measurement: Hematoxylin and eosin staining and TRAP, histological slide examination.;Alkaline phosphatase activity. Timepoint: 4 months after surgery. Method of measurement: MultiSkanGo plate reader software.;Issue mineralization rate. Timepoint: 4 months after surgery. Method of measurement: Investigation of mineralized areas in histological slide examination.;Number of cells per unit area. Timepoint: 4 months after surgery. Method of measurement: Histological slide examination and MutikImage 2 software.;Gene expansion. Timepoint: 4 months after surgery. Method of measurement: Reverse transcription PCR.;Horizontal dimension of bone. Timepoint: 4 months after surgery. Method of measurement: Calculation from CBCT radiography.;Hansfield number. Timepoint: 4 months after surgery. Method of measurement: Calculation from CBCT radiography.	—

Measure

Time frame

The amount of collagen. Timepoint: 4 months after surgery. Method of measurement: Hematoxylin and eosin staining and TRAP, histological slide examination.;Alkaline phosphatase activity. Timepoint: 4 months after surgery. Method of measurement: MultiSkanGo plate reader software.;Issue mineralization rate. Timepoint: 4 months after surgery. Method of measurement: Investigation of mineralized areas in histological slide examination.;Number of cells per unit area. Timepoint: 4 months after surgery. Method of measurement: Histological slide examination and MutikImage 2 software.;Gene expansion. Timepoint: 4 months after surgery. Method of measurement: Reverse transcription PCR.;Horizontal dimension of bone. Timepoint: 4 months after surgery. Method of measurement: Calculation from CBCT radiography.;Hansfield number. Timepoint: 4 months after surgery. Method of measurement: Calculation from CBCT radiography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAdileh Shirmohammadi

Tabriz University of Medical Sciences

hamidreza.mohammadi.pajuhan@gmail.com+98 44 3344 4598

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026