non alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: A capsule containing 500 mg of chamomile flower powder will be taken four times a day, two fasting morning and two nights before bedtime for three months. Intervent
Sponsors
Fasa University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: sign the consent form age between 25-65 years BMI between 22-35 Diagnosis of fatty liver and steatohepatitis with: A- serum level of Alanine Transaminease (ALT) More than one and a half times the highest normal limit(66/5000This means that more than 45 men and women more than or equal to 29 units per liter)Also, the amount of aspartate transaminase (AST) In both sexes is greater than 30 units per liter(According to the latest definition of ALT and abnormal AST in men and women). B- Diagnosis of fatty liver (moderate to high) in liver ultrasound. The patient have not to consume lipid regulating drugs for four weeks The patient have not to consume some drugs like silybin, ursodeoxycholic acid, Polyene Phosphatidylcholine, vitamin E and Medicinal herbs with blood lipid regulation effect and hepatoprotective effect from four weeks bfore entering to the study.
Exclusion criteria
Exclusion criteria: pregnancy and lactation Liver failure (acute or chronic) Liver diseases such as autoimmune hepatitis, viral hepatitis B and C (active or inactive), Wilson's disease and etc. Hypo and hyperthyroidism Renal failure (creatinine above 1.5 mg / dL) Any malignancy (treated or not) Taking warfarin Addiction and alcohol consumption Taking contraceptives, ouroso-doxycyclic acid, glucocorticoid, statins, probiotics, vitamin E over the past three months Chamomile allergy history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatty liver grade. Timepoint: Initially and three months later. Method of measurement: Ultrasound.;Hepatic aminotransferases. Timepoint: Initially and six weeks later and three months later. Method of measurement: Laboratory Kit.;Fatty liver index(FLI). Timepoint: Initially and three months later. Method of measurement: Using formula: [e 0.953*loge (triglycerides) + 0.139*BMI + 0.718*loge (ggt) + 0.053*waist circumference - 15.745) / (1 + e 0.953*loge (triglycerides) + 0.139*BMI + 0.718*loge (ggt) + 0.053*waist circumference - 15.745)] × 100.;Alpha Tumor Necrosis Factor. Timepoint: Initially and three months later. Method of measurement: Laboratory Kit.;Insulin resistance index. Timepoint: Initially and three months later. Method of measurement: Calculate the HOMA-IR.;Alkaline phosphatase. Timepoint: initially and three months later. Method of measurement: Laboratory Kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass composition. Timepoint: At the entrance and three months later. Method of measurement: Body mass composition machine.;Inflammation. Timepoint: At the entrance and three months later. Method of measurement: hs-CRP labratory kit.;Lipide profile. Timepoint: At the entrance and three months later. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSadegh amiri
Fasa University of Medical Sciences
Outcome results
None listed