Effect of Green Tea on Methadone Maintenance Patients

The effect of green tea enriched with EGCG on some inflammatory, antioxidant and cognitive factors in methadone maintenance patients; Triple-blind clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180902040927N5

Enrollment

Registered

2021-04-18

Start date

2021-04-21

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention 1: Intervention group: To receive 60 mg capsules containing green tea enriched with 40% effective epigallocatechin gallate twice daily for 3 months. Intervention 2: Control group: To rece

Eligibility

Sex/Gender

Male

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with methadone maintenance are 20 and 70 years old. Patients who have completed the Consent form. People who have not an underlying inflammatory or infectious disease.

Exclusion criteria

Exclusion criteria: Patients who are allergic to green tea. Patients are taking antioxidant supplements daily and regularly. People who have a special diet like vegetarian. People who consumed green tea daily before the study

Design outcomes

Primary

Measure	Time frame
C-reactive protein. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: ELISA method.;Tumor necrosis factor -a. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: ELISA method.;Total antioxidant capacity. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Superoxide dismutase. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Catalase. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Glutathione peroxidase. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Reactive oxygen species. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Addiction Severity Index. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Addiction Severity Index questionnaire.	—

Measure

Time frame

C-reactive protein. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: ELISA method.;Tumor necrosis factor -a. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: ELISA method.;Total antioxidant capacity. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Superoxide dismutase. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Catalase. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Glutathione peroxidase. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Reactive oxygen species. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Spectrophotometric method.;Addiction Severity Index. Timepoint: Before taking drug and after 3 months of taking drug. Method of measurement: Addiction Severity Index questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdieh Azin

Rafsanjan University of Medical Sciences

mahdieh.azin@gmail.com+98 34 3131 5079

Outcome results