Salbutamol and neonatal respiratory distress syndrome

Evaluation of the effect of intratracheal Salbutamol in addition to Surfactant on clinical course of neonates with respiratory distress syndrome with gestational age less than 34 weeks and 7 days and more than 1000 g weight

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180826040877N1

Enrollment

Registered

2019-01-15

Start date

2017-03-21

Completion date

Unknown

Last updated

2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory distress syndrome. Respiratory distress syndrome of newborn

Interventions

Intervention 1: Intervention group: Neonates in intervention group are first treated with Surfactant (2.5ml/kg) and 8 hours after initial dose, subsequent dose (1.25 ml/kg) is received. After receivin

Eligibility

Sex/Gender

All

Age

No minimum to 245 Days

Inclusion criteria

Inclusion criteria: Age less tan 34 weeks and 7 days Weight more than 1000 grams Documented respiratory distress syndrome based on clinical findings and chest- X- Ray

Exclusion criteria

Exclusion criteria: Birth trauma Major congenital anomalies Perinatal asphyxia Five minutes apgar score <=3 Severe metabolic acidosis at birth Positive blood culture Parent's unwillingness

Design outcomes

Primary

Measure	Time frame
INSURE Failure. Timepoint: During hospitalization. Method of measurement: Clinical examination.;Duration of N-CPAP need. Timepoint: During hospitalization. Method of measurement: observation.;Duration of oxygen need. Timepoint: During hospitalization. Method of measurement: observation.;Mortality. Timepoint: During hospitalization. Method of measurement: observation.;Duration of hospitalization. Timepoint: During hospitalization. Method of measurement: Extract from patient's profile.	—

Measure

Time frame

INSURE Failure. Timepoint: During hospitalization. Method of measurement: Clinical examination.;Duration of N-CPAP need. Timepoint: During hospitalization. Method of measurement: observation.;Duration of oxygen need. Timepoint: During hospitalization. Method of measurement: observation.;Mortality. Timepoint: During hospitalization. Method of measurement: observation.;Duration of hospitalization. Timepoint: During hospitalization. Method of measurement: Extract from patient's profile.

—

Secondary

Measure	Time frame
Pneumothorax. Timepoint: During hospitalization. Method of measurement: Chest X ray.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRazieh Goudarzi

Esfahan University of Medical Sciences

dr.goudarzi1984@gmail.com+98 917 368 2967

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026